Condoms: So Many Choices, So Little Time Be Well and Thrive Always use water or silicone based condom safe approved lubricants Condoms protect against unplanned pregnancy and most sexually transmitted infections, including HIV, gonorrhoea, chlamydia, and syphilis. Use only water or silicone based lubricant with a condom during vaginal and particularly anal sex Self lubricating condoms may help raise condom usage : . . Not all lubricants are the same, and choosing the right one can make sex safer and more comfortable. Water Based Lube The most commonly recommended